PfEMP1-DBL1 amino acid motifs in severe disease states of Plasmodium falciparum malaria
نویسندگان
چکیده
منابع مشابه
Virulence in Plasmodium falciparum malaria: mechanisms of PfEMP1-mediated rosetting
Malaria is one of the most important infectious diseases in the world and the Plasmodium falciparum parasite is the causative agent of most of the severe cases. The pathogenesis of the disease is complex but sequestration and hence microvascular obstruction is associated with virulence of the parasite. Rosetting, the adhesion of a parasitized red cell (pRBC) to two or more non-parasitized RBC i...
متن کاملSevere Plasmodium falciparum malaria Malária grave por Plasmodium falciparum
Malaria is the world’s leading parasitic disease and affects approximately 40% of the world’s population (approximately 2.4 billion people) in more than 100 countries.(1) The disease, that is caused for Plamodium spp., particularly affects populations in tropical and subtropical areas, especially in developing and underdeveloped countries. Brazil has the largest number of cases on the American ...
متن کاملPlasmodium falciparum antigenic variation: relationships between widespread endothelial activation, parasite PfEMP1 expression and severe malaria
BACKGROUND Plasmodium falciparum erythrocyte membrane protein 1(PfEMP1) is a family of variant surface antigens (VSA) that mediate the adhesion of parasite infected erythrocytes to capillary endothelial cells within host tissues. Opinion is divided over the role of PfEMP1 in the widespread endothelial activation associated with severe malaria. In a previous study we found evidence for different...
متن کاملPlasmodium falciparum Associated with Severe Childhood Malaria Preferentially Expresses PfEMP1 Encoded by Group A var Genes
Parasite-encoded variant surface antigens (VSAs) like the var gene-encoded Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) family are responsible for antigenic variation and infected red blood cell (RBC) cytoadhesion in P. falciparum malaria. Parasites causing severe malaria in nonimmune patients tend to express a restricted subset of VSA (VSA(SM)) that differs from VSA associated...
متن کاملMicrovascular dysfunction in severe Plasmodium falciparum Malaria.
TO THE EDITOR—Hanson and colleagues present a commendable attempt to determine the relative contribution of macrovascular and microvascular dysfunction in severe Plasmodium falciparum malaria [1]. The number of capillaries with impaired flow correlated with the severity of illness and central venous lactate, whereas most indices of macrovascular function did not [1]. Thus, this study demonstrat...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2007
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.0610485104